Therapeutic schemes of denosumab in the treatment of giant cell tumor of bone - Protocol for a systematic review with meta-analysis

The aim of this study is to evaluate the efficacy different therapeutic regimens using denosumab in patients with giant cell tumor bone (GCTB), regarding primary outcomes related response (lesion size, pain and function) presentation imaging exams, addition secondary age (in years) location, reduction or downgrade surgical indication, local recurrence, presence pulmonary metastases side effects. A systematic literature search will be carried out PubMed/MEDLINE, Embase (CAPES Journals), Science Direct/Elsevier, Scielo, Cochrane Library clinical trial records (ClinicalTrials.gov Registro Brasileiro de Ensaios Clínicos) databases; for exploration grey literature, Open Access Theses Dissertations Biblioteca Digital Brasileira Teses e Dissertações databases consulted. We also conduct a "snowball" survey identify additional eligible studies full-text review. Two evaluators select, extract assess risk bias obtained data. If appropriate, meta-analysis out, extracting data number events total perform proportion R software, "meta" package (version 4.9–6), "metaprop function" aspect ratio results review provide convincing information on GCTB, providing reliable theoretical basis research that follow.